Atypical Role for PhoU in Mutagenic Break Repair under Stress in Escherichia coli
نویسندگان
چکیده
منابع مشابه
Atypical Role for PhoU in Mutagenic Break Repair under Stress in Escherichia coli
Mechanisms of mutagenesis activated by stress responses drive pathogen/host adaptation, antibiotic and anti-fungal-drug resistance, and perhaps much of evolution generally. In Escherichia coli, repair of double-strand breaks (DSBs) by homologous recombination is high fidelity in unstressed cells, but switches to a mutagenic mode using error-prone DNA polymerases when the both the SOS and genera...
متن کاملRoles of Nucleoid-Associated Proteins in Stress-Induced Mutagenic Break Repair in Starving Escherichia coli.
The mutagenicity of DNA double-strand break repair in Escherichia coli is controlled by DNA-damage (SOS) and general (RpoS) stress responses, which let error-prone DNA polymerases participate, potentially accelerating evolution during stress. Either base substitutions and indels or genome rearrangements result. Here we discovered that most small basic proteins that compact the genome, nucleoid-...
متن کاملPersistent damaged bases in DNA allow mutagenic break repair in Escherichia coli
Bacteria, yeast and human cancer cells possess mechanisms of mutagenesis upregulated by stress responses. Stress-inducible mutagenesis potentially accelerates adaptation, and may provide important models for mutagenesis that drives cancers, host pathogen interactions, antibiotic resistance and possibly much of evolution generally. In Escherichia coli repair of double-strand breaks (DSBs) become...
متن کاملTypical & atypical enteropathogenic Escherichia coli in diarrhoea & their role as carrier in children under five
BACKGROUND & OBJECTIVES Multidrug-resistant enteropathogenic Escherichia coli (EPEC) is responsible for a large number of cases of infantile diarrhoea in developing countries, causing failure in treatment with consequent health burden and resulting in a large number of deaths every year. This study was undertaken to determine the proportion of typical and atypical EPEC in under five children wi...
متن کاملAtypical Escherichia coli in streams.
In the examination of stream waters for fecal coliforms, pale yellow colonies regularly appeared on m-FC broth base medium plates. The yellow colonies may comprise 70% more of the colonies of an m-FC plate. More than 80% of these colonies were identified as Escherichia coli by the API 20E identification system and by serotyping. The atypical yellow E. coli strains were not environmentally stres...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0123315